Hello, A recent article in The Economist is titled "The battle over the trillion-dollar weight-loss bonanza." What? You've probably heard about the new weight-loss drugs such as Wegovy and Zepbound (called GLP-1 agonists), which can quickly reduce a person's body weight by 15%. That's 30 pounds lost if you weigh 200 pounds. The Economist is predicting that annual sales of these drugs may reach $80 billion by 2030. Close to half the world's population is predicted to be obese or overweight by 2030 (World Obesity Federation). So, a trillion dollars in sales over a few years is not a stretch. Except... In the history of pharmaceuticals, there has never been a product that was used by patients long-term that didn't develop side effects. Generally, the more powerful the drug, the worse the side effects, as the chemical disrupts normal body functions. These weight-loss drugs must be used for life and already have severe side effects (nausea, muscle loss, loss of enjoyment of foods). There is no predicting what happens after a person takes them for 10+ years. Then, there's human nature. As a species, we are not exceptionally good at doing things we don't like unless there are consequences. Many overweight people live much healthier lifestyles to control their weight. Would they continue to eat well and exercise if they could take a drug and live any way they wanted? | 
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